Inflammatory signaling compromises cell responses to interferon alpha

Inhibition of alpha interferon signaling by hepatitis B virus.

Alpha interferon (IFN-alpha) and pegylated IFN-alpha (pegIFN-alpha) are used for the treatment of chronic hepatitis B (CHB). Unfortunately, only a minority of patients can be cured. The mechanisms responsible for hepatitis B virus (HBV) resistance to pegIFN-alpha treatment are not known. pegIFN-alpha is also used to treat patients with chronic hepatitis C (CHC). As with chronic hepatitis B, man...

Correlation Between Interferon Alpha Receptor Protein Expression and Sensitivity to Interferon Alpha Subtypes in Human Renal Carcinoma Cell Lines

1109-6535/2004 $2.00+.40 Abstract. Background: We have previously characterized the antitumor activities and immunological properties of interferon-alpha (IFN-·) subtypes on renal cell carcinoma (RCC). However, the mechanism responsible for the different biologic activities among the IFN-· subtypes is still unclear. To explain the different cellular sensitivities to IFN-· subtypes, detailed exp...

Impaired alpha-interferon signaling in transitional cell carcinoma: lack of p48 expression in 5637 cells.

The limited success of IFN-alpha therapy for clinical treatment of transitional cell carcinoma (TCC) has prompted us to investigate the responsiveness of TCC lines to IFN-alpha. The response to IFN-alpha in terms of 561 gene induction, an IFN-stimulated response element-containing IFN-alpha/beta-inducible gene, and IFN-stimulated gene factor 3 (ISGF3) formation was normal in primary human uroth...

Interleukin-1β Signaling in Dendritic Cells Induces Antiviral Interferon Responses

Induction of interferon beta (IFN-β), IFN-stimulated genes (ISGs), and inflammatory responses is critical for control of viral infection. We recently identified an essential linkage of stimulation of the inflammatory cytokine interleukin-1β (IL-1β) and induction of ISGs that function as host restriction pathways against the emerging flavivirus West Nile virus (WNV) in vivo Here we utilized ex v...

Inflammatory Responses to Pneumovirus